Kelley and Firestein’s Textbook of Rheumatology 2 Volume Set (10th Edition)

DescriptionConsult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein Ralph C. Budd Sherine E. Gabriel Iain B. McInnes and James R. O’Dell and authored by internationally renowned scientists and clinicians in the field Kelley and Firestein’s Textbook of Rheumatology 10th Edition delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science immunology anatomy and physiology to diagnostic tests procedures and specific disease processes this state-of-the-art reference provides a global authoritative perspective on the manifestations diagnosis and treatment of rheumatic diseases.New to this EditionNew content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases.New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.More schematic diagrams clearly summarize information and facilitate understanding.Key FeaturesAn ideal balance of the basic science you need to know and how to apply that information to clinical practice.An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes.Videos online demonstrate the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints.Table of ContentsBiology of the Normal JointSynoviumCartilage and ChondrocytesBiology, Physiology, and Morphology of BoneMuscle: Anatomy, Physiology, and BiochemistryBiomechanicsTissue EngineeringProteinases and Matrix DegradationDendritic CellsMACROPHAGESNeutrophilsT LymphocytesB CellsFibroblasts and Fibroblast-like SynoviocytesMast CellsPlatelets and Rheumatic DiseasesInnate ImmunityADAPTIVE IMMUNITY and Organization of Lymphoid TissuesAutoimmunityMETABOLIC REGULATION IN IMMUNITYGenetics of Rheumatic DiseasesEpigenetics of rheumatic diseasesComplement SystemProstaglandins, Leukotrienes, and Related CompoundsCell Recruitment and AngiogenesisCytokinesPRINCIPLES OF SIGNALINGCell Survival and Death in Rheumatic DiseasesAnimal Models of Rheumatic DiseasesNeural regulation of Pain and InflammationRESEARCH METHODS IN THE RHEUMATIC DISEASESBURDEN OF THE RHEUMATIC DISEASEAssessment of Health Outcomes IN RHEUMATIC DISEASESBiologic MarkersOccupational and Recreational MSK DisordersCardiovascular Risk in Rheumatic DiseaseCancer Risk in Rheumatic DiseasesIntroduction to Physical Medicine, Physical Therapy and RehabilitationPregnancy and Rheumatic DiseasesHistory and Physical Examination of the Musculoskeletal SystemEVALUATION AND DIFFERENTIAL DIAGNOSIS OF Monoarticular ArthritisEVALUATION AND DIFFERENTIAL DIAGNOSIS OF Polyarticular ArthritisThe Skin and Rheumatic DiseasesThe Eye and Rheumatic DiseasesNeck PainShoulder PainLow Back PainHip and Knee PainAnkle and Foot PainHand and Wrist PainTemporomandibular Joint PainFibromyalgiaSynovial Fluid Analysis, Synovial Biopsy, and Synovial PathologyArthrocentesis and Injection of Joints and Soft TissueAntinuclear AntibodiesAutoantibodies in rheumatoid arthritisAcute Phase ReactantsImaging Modalities in Rheumatic DiseaseProstanoid Biology and its Therapeutic TargetingGlucocorticoid TherapyTraditional DMARDS: Methotrexate, Leflunomide, Sulfasalazine, and Hydroxychloroquine and Combination TherapiesTRADITIONAL Immunoregulatory DrugsAnticytokine TherapiesCell Targeted BiologicsNOVEL INTRACELLULAR TARGETING AGENTSUrate Lowering TherapyAnalgesic Agents in Rheumatic DiseasesNutrition and Rheumatic DiseaseEtiology and Pathogenesis of Rheumatoid ArthritisClinical Features of Rheumatoid ArthritiTreatment of Rheumatoid ArthritisEarly Synovitis and Early Undifferentiated ArthritisSjogren’s SyndromeEtiology and Pathogenesis of SpondyloarthropathiesAnkylosing SpondylitisUndifferentiated Spondyloarthritis and Reactive ArthritisPsoriatic ArthritisEnteropathic ArthritisEtiology and Pathogenesis of SLEClinical Features of SLETreatment of SLEAntiphospholipid SyndromeEtiology and Pathogenesis of SclerodermaClinical Features and Treatment of SclerodermaInflammatory Diseases of Muscle and Other MyopathiesOverlap SyndromesClassification and Epidemiology of Systemic VasculitisGiant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s ArteritisAntineutrophil Cytoplasmic Antibody-Associated VasculitisPolyarteritis and Related DisordersImmune Complex-Mediated Small Vessel VasculitisIsolated Angiitis of the Nervous SystemBechet’s DiseaseEtiology and Pathogenesis of Gout and HyperuricemiaClinical Features and Treatment of GoutCalcium Crystal Diseases: Calcium Pyrophosphate Dihydrate and Basic Calcium PhosphateFamilial Autoinflammatory SyndromesEtiology and Pathogenesis of OsteoarthritisClinical Features of OsteoarthritisTreatment of OsteoarthritisMetabolic Bone DiseaseProliferative Bone DiseaseOsteonecrosisRelapsing PolychondritisHeritable Diseases of Connective TissueEtiology and Pathogenesis of Juvenile Idiopathic ArthritisTreatment of Juvenile Inflammatory ArthritisSLE, Juvenile Dermatomyositis, Scleroderma and VasculitisBacterial ArthritisLyme DiseaseMycobacterial Infections of Bones and JointsFungal Infections of Bones and JointsRheumatic Manifestations of HIV InfectionViral ArthritisRheumatic Fever and Post-Streptococcal ArthritisAmyloidosisSarcoidosisHemachromotosisHemophilic ArthropathyRheumatic Manifestations of HemoglobinopathiesIgG4-RELATED DISEASESArthritis Accompanying Endocrine and Metabolic DisordersMusculoskeletal Syndromes Associated with MalignancyTumors and Tumor-like Lesions of Joints and Related StructuresAuthors BiographyGary S. Firestein, MD, Distinguished Professor of Medicine, Dean and Associate Vice Chancellor of Translational Medicine, University of California San Diego School of Medicine, La Jolla, CaliforniaRalph C. Budd, MD, Professor of Medicine and Microbiology and Molecular Genetics, Director, Vermont Center for Immunology and Infectious Diseases, University of Vermont College of Medicine Distinguished University Professor, The University of Vermont College of Medicine, Burlington, VermontSherine E Gabriel, MD, MSc, Professor and Dean, Rutgers Robert Wood Johnson Medical School, CEO, Robert Wood Johnson Medical Group, Emeritus Professor, Mayo Clinic, New Brunswick, New JerseyIain B McInnes, PhD, FRCP, FRSE, FMedSci, Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection, Immunity, and Inflammation , College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United KingdomJames R O’Dell, MD, Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska